Author: Hanafy, M S: Hatem, M E
Citation: J-Ethnopharmacol. September 1991; 34 (2-3): 275-8
• Black Seed Research of antibiotic activity against gram-positive bacterium Staphylococcus aureus, gram-negative bacteria Pseudomonas aeruginosa and E. coli.
• The in vitro anti-tumor activity of Some crude and purified components of blackseed, Nigella sativa L. Worthen DR, Ghosheh OA, Crooks PA.
Natural Products Chemistry Laboratory, Tobacco and Health Research Institute, Lexington, KY 40536, USA. Anticancer Res 1998 May-Jun 18 (3A) :1527-32
• Research anticancer effect of powders, oils and Seed components of several Multi Drug Resistant (MDR) human tumor cell lines. Results showed Black Seed has cytotoxic effects against several types of human tumor cells.
• The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa
M. S. Al-Ghamdi. Department of Pharmacology, King Faisal University, College of Medicine, PO Box 2114, Dammam 31451, Saudi Arabia, 27 January 2001
• Research is proving that Black Seed has the effect of anti-inflammatory, analgesic (pain killer), and decreased heat.
• A new and novel treatment of opioid dependence: Nigella sativa 500 mg.
Sangi S, Ahmed SP, Channa MA, Ashfaq M, Mastoi BC. Department of Pharmacology, Fatima Jinnah Dental College, Karachi. J Ayub Med Coll Abbottabad. 2008 Apr-Jun.
• Seed Treatment with 500 mg long-term / long term, reduce dependence on opioid drugs.
• pharmacological and toxicological properties of Nigella sativa.
Ali BH, Blunden G. Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem 81 999, Saudi Arabia. Phytother Res. 2003 April; 17 (4) :299-305.
• Studies show pharmacological effects in protecting kidney Seed and hepatic (liver). The study also revealed the efficacy of anti-inflammatory, analgesic, antipyretic, antimicrobial and anticancer of Black Seed powder or oil. Black Seed Oil researched to lower blood pressure and increased respiration. Tests on mice showed Habbat can increase hemoglobin and blood cell components. And reduce the concentration of cholesterol, triglycerides and glucose in blood plasma. Research shows also that toxicitas Black Seed is very low. And no side effects to the liver and kidney.
• Protects Thymoquinone dopaminergic neurons against MPP + and rotenone.
Radad K, Moldzio R, Taha M, Rausch WD. Pathology Department, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
• initial research and first-time showing potential thymoquinon (within habbatusauda) protect primary dopaminergic neurons, MPP face (+) and rotenon. This is beneficial for patients with Parkinson's.
• antihypertensive effect of Nigella sativa seed extract in Patients with mild hypertension.
Dehkordi FR, Kamkhah AF. Department of Internal Medicine and Cardiology and Medicinal Plant Research Center, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. Fundam Clin Pharmacol. 2008 Aug; 22 (4) :447-52
• Research is proving that with the use of extract of Black Seed 200 mg 2 times a day, can reduce mild high blood pressure within 2 months of usage.
• symptomatic treatment of acute pharyngitis tonsillo-Patients with a combination of Nigella sativa and Phyllanthus niruri extract. Dirjomuljono M, Kristyono I, Tjandrawinata RR, Nofiarny D. Department of Ear, Nose, Throat, Faculty of Medicine, University of Airlangga / Dr. Soetomo General Hospital, Surabaya, Jakarta, Indonesia. Int J Clin Pharmacol Ther. 2008 June; 46 (6) :295-306
• Study that proved that Black Seed 360 mg combined with 50 mg meniran and consumed 3 times a day, can assist treatment of acute tonsilopharingitis (tonsils).
• The effect of Nigella sativa L. (Black cumin seed) on intractable pediatric seizures.
Akhondian J, Parsa A, Rakhshande H.
Department of Pediatrics and Pediatric Neurology, Mashhad University of Medical Sciences, Ghaem Medical Center, Mashhad, Iran. Med Sci monit. 2007 Dec; 13 (12): CR555-9.
• Research shows that water extract of Black Seed with a dose of 40 mg / kg / 8 hours, to give effect antiepileptik in patients with refractory epileptic seizures.
• The possible prophylactic effect of Nigella sativa seed extract in asthmatic Patients.
Boskabady MH, Javan H, Sajady M, Rakhshandeh H. Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad 91735, Iran
Fundam Clin Pharmacol. 2008 February; 22 (1): 105
• This study demonstrated that Black Seed can be recommended as prophylactic therapy in patients with asthma. The dose used was 15 mL / kg of 0.1 g% Boiled extract.
• Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells. Norwood AA, Tan M, May M, Tucci M, Benghuzzi H.
School of Health Related Professions, University of Mississippi Medical Center Jackson, Mississippi 39216, USA. BioMed Sci instrum. 2006; 42:350-6.
• This study shows that the effects of chemotherapy on cancer cells of the Black Seed (Thymoquinon) equivalent to 5-fluoruracil.
• Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Rooney S, Ryan MF.
Department of Zoology, University College Dublin, Belfield, Dublin 4, Ireland.
Anticancer Res. 2005 May-Jun; 25 (3B) :2199-204
• This study shows the effect of alpha hederin and thymoquinone which is the womb of Black Seed on the cancer cell lung carcinoma A549, Hep-2 (larynx epidermoid carcinoma), HT-29 (colon adenocarcinoma) and MIA Paca-2 (pancreatic carcinoma).
• The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions.
El-Dakhakhny M, Mady N, Lembert N, Ammon HP. Planta Med. 2002 May; 68 (5) :465-6
• This study describes likely that the effects of Black Seed hypoglikemik mediated by the activity outside the pancreas and not in the pancreas.
• Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters K. M. Fararha, Y. Atojib, Y. Shimizua, T. Shiinaa, H. Nikamia and T. Department of Physiology and Pathogenetic Veterinary Sciences, The United Graduate School, Gifu University, 1-1 Yanagido, 501-1193, Gifu, Japan
Department of Anatomy, The United Graduate School, Gifu University, 501-1193, Gifu, Japan. Received 12 March 2004. Available online 2 June 2004.
• This study shows that the effects of Black Seed hypoglikemik is to decrease hepatic gluconeogenesis. While it is imunopotensiasi effect through stimulation of macrophage phagocytic activity and the activity lymposit.
• Effect of Nigella sativa Volatile Oil on Jurkat T Cell Leukemia Polypeptides
Nabil Hailat, Ziad Bataineh, Shawkat Lafi, Raweily Essam, Mahmoud Aqel, Mohamad Al-Katib and Sam Hanash. Molecular Pathology Laboratory, Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology (Irbid). Department of Anatomy, Jordan University of Science and Technology (Irbid)
Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology (Irbid). Department of Anatomy, University of Jordan (Amman), Jordan. Department of Microbiology, University of Jordan (Amman), Jordan. Department of Pediatric Haematology, University of Michigan, Ann Arbor, MI, USA. Assistant Professor of Immunopathology, Head of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid-Jordan. Pharmaceutical Biology
1995, Vol. 33, No. 1, Pages 16-20, DOI 10.3109/13880209509088141
• This research studies the effects of Black Seed on the Jurkat T cell leukemia.
• Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Farah,-I-O; Begum,-R-A. BioMed-Sci-instrum. 2003; 39: 359-64.
• The study concluded that Black Seed, either alone or combined with antioxidative stress was found effective in vitro to inhibit the growth of breast cancer cells MCF-7. This opens the possibility for use as an ingredient habbatusauda therapy and prevention of cancer.
• Androgen Receptor-and E2F-1-Targeted Therapy for Hormone Thymoquinone-Refractory Prostate Cancer. Ahmed O. Kaseb, Kannagi Chinnakannu, Di Chen, Arun Sivanandam, Sheela Tejwani, Mani Menon, Q. Ping Dou and G. Prem-Veer Reddy
Department of Hematology / Oncology and Vattikuti Urology Institute, Henry Ford Hospital, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan. Requests for Reprints: G. Prem-Veer Reddy, Vattikuti Urology Institute, Henry Ford Health System, One Ford Place, 2D, Detroit, MI 458 202. Phone: 313-874-5991, 313-874-5991; American Association for Cancer Research; Cancer Res 2007; 67 (16) :7782-8
• The study concludes that thymoquinone can be used as material for prostate cancer therapy.
• Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing Akt and extracellular signal-regulated kinase signaling pathways
1. Tingfang Yi1,
2. Sung-Gook Cho1,
3. Zhengfang Yi3,
4. Xiufeng Pang13,
5. Melissa Rodriguez1,
6. Ying Wang1,
7. Gautam Sethi2,
8. Bharat B. Aggarwal2 and
9. Mingyao Liu1
Accepted April 18, 2008. Received February 4, 2008. Revision received April 12, 2008.
Grant support: National Cancer Institute / NIH grant 1R01CA106479. American Association for Cancer Research
• This study shows that thymoquinone inhibit the process of tumor angiogenesis and inhibit tumor growth. Advice from researchers that the Black Seed (Thymoquinone) could be potential candidates for cancer therapy in the future. Taken from the seminar dr. Insan Agung Nugroho at the National Gathering, July 12, 2009 in the building-Hajj Daarul Daarut Tauhid Bandung. Last Updated (Wednesday, September 30, 2009 12:51)
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